Sensitive assay for the detection of cyclic nucleotides by mass spectrometry
نویسندگان
چکیده
Background cAMP and cGMP have been known for a long time to be important second messengers in living cells, whereas other cyclic nucleotides like cCMP or cUMP have only been on the fringes of scientific interest. Recently, our group has discovered that bacterial adenylyl cyclase toxins produce a number of different cyclic nucleoside 5'-monophosphates (cNMPs) apart from cAMP, and the interest in specific and sensitive detection methods rises.
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2009